Sorbicillinoid Derivatives From Sponge-Derived FungusTrichoderma reesei(HN-2016-018)

Six new sorbicillinoids, trichoreeseione A (1) and B (2), trichodermolide B (3), 13-hydroxy-trichodermolide (4), 24-hydroxy-trichodimerol (5), 15-hydroxy-bisvertinol (7), together with three known analogs, trichodimerol (6), 24-hydroxy-bisvertinol (8), and bisvertinol (9), were isolated from the sponge-derived fungusTrichoderma reesei(HN-2016-018). Their structures including absolute configurations were elucidated by analysis of NMR, MS data, and calculated ECD spectra. Compounds1and2with a characteristic naphthalene-trione ring were firstly reported in sorbicillinoid family. Compounds3and4were two rare sorbicillinoids containing a unique bicycle [3.2.1] lactone skeleton, while3with a propan-2-one moiety was also recorded first time in this family. Compound5displayed cytotoxic activity against A549, MCF-7, and HCT116 cell lines with the IC(50)values of 5.1, 9.5, and 13.7 mu M, respectively.