期刊
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
卷 10, 期 -, 页码 -出版社
FRONTIERS MEDIA SA
DOI: 10.3389/fcimb.2020.00336
关键词
atopic dermatitis; skin microbiota imbalance; clinical treatment; children; China
资金
- Beijing Municipal Administration of Hospitals' Youth Programme [QML20151101]
- Beijing Municipal Administration of Hospitals Clinical Medicine Development of Special Funding Support [ZYLX201601]
- National Natural Science Foundation of China [81673042]
- Beijing Children's Hospital Young Investigator Program [BCHYIPA-2016-11]
- National Institutes of Health/NCI Cancer Center Support Grant P30 [CA008748]
- Special Fund of The Pediatric Medical Coordinated Development Center of Beijing Municipal Administration [XTZD20180502]
- Beijing Talents Fund [2017000021469G248]
- Zlinkoff and C & D Funds, and Nutrition and Care of Maternal & Child Research Fund Project of Biostime Institute of Nutrition Care [BINCMYF15009]
Background:Atopic dermatitis (AD) is a common cutaneous disease, associated with imbalances in the skin microbiota. Objective:To explore the characteristics of the cutaneous microbiota and its dynamic changes during clinical treatment. Methods:Cutaneous swab samples were collected from 51 AD patients before treatment, and 40 AD patients remained after a 2-week treatment with mometasone and mupirocin. Results:AD patients exhibited significant enrichments ofPrevotellaandDesulfovibrioas well as obvious reductions ofCorynebacterium, StreptococcusandParabacteroides. Based on the proportion ofStaphylococcus aureus, the AD patients were further classified intoS. aureus-predominant group (AD.S) andS. aureus-non-dominant (AD.ND) group. The AD.S group exhibited lower skin microbial diversity and higher atopic dermatitis (SCORAD) index. In the AD.S group, the cutaneous microbial diversity significantly increased from 2.9 +/- 0.8 to 3.7 +/- 1.0, while the relative abundance ofS. aureusdecreased from 42.5 +/- 20.7 to 10.3 +/- 28.4 after treatment. In contrast, no significant skin microbiota changes were detected in the AD.ND group. Conclusions:AD patients with predominantS. aureushad higher disease severity and lower microbiota diversity compared to patients in the AD.ND group. Mometasone and mupirocin therapy had significant effects on skin microbiota in AD.S patients, but had a paradoxical response in the AD.ND patients.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据