期刊
WILEY INTERDISCIPLINARY REVIEWS-RNA
卷 12, 期 2, 页码 -出版社
WILEY
DOI: 10.1002/wrna.1612
关键词
autoimmune diseases; cancer; heterogeneous nuclear ribonucleoprotein A2; B1; neurodegenerative diseases; RNA processing
类别
资金
- National Natural Science Foundation of China [81272921, 81670542]
The RNA-binding protein hnRNPA2/B1 plays crucial roles in recognizing and binding specific RNA substrates and DNA motifs, regulating the transcription, splicing, and translation of various RNA molecules, in addition to being involved in telomere maintenance, DNA repair, and the development of tumors and neurodegenerative diseases.
The RNA-binding protein hnRNPA2/B1 is a member of the hnRNPs family and is widely expressed in various tissues. hnRNPA2/B1 recognizes and binds specific RNA substrates and DNA motifs and is involved in the transcription, splicing processing, transport, stability, and translation regulation of a variety of RNA molecules and in regulating the expression of a large number of genes. hnRNPA2/B1 is also involved in telomere maintenance and DNA repair, while its expression changes and mutations are involved in the development of various tumors and neurodegenerative and autoimmune diseases. This paper reviews the role and mechanism of hnRNPA2/B1 in RNA metabolism, tumors, and neurodegenerative and autoimmune diseases. This article is categorized under: RNA Interactions with Proteins and Other Molecules > Protein-RNA Interactions: Functional Implications RNA in Disease and Development > RNA in Disease
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据