期刊
POLYMERS
卷 12, 期 7, 页码 -出版社
MDPI
DOI: 10.3390/polym12071445
关键词
chitosan; carboxymethyl chitosan; molecular weight; antioxidant properties; skin moisturizing
资金
- National Research Council of Thailand (NRCT)
- Thailand Institute of Scientific and Technological Research (TISTR)
- Center of Excellence in Materials Science and Technology, Chiang Mai University
- Chiang Mai University under the Cluster of Agro Bio-Circular-Green Industry [CMU-8392(10)/W.152-12032020]
This research aimed to synthesize carboxymethyl chitosan (CMCH) from different molecular weights of chitosan including low MW (L, 50-190 kDa), medium MW (M, 210-300 kDa) and high MW (H, 310-375 kDa) on the antioxidant and moisturizing properties. The L-CMCH, M-CMCH and H-CMCH improved the water solubility by about 96%, 90% and 89%, respectively when compared to native chitosan. Higher MW resulted in more viscous of CMCH. For antioxidant properties, IC(50)values of DPPH and ABTS radical scavenging activity for L-CMCH were 1.70 and 1.37 mg/mL, respectively. The L-CMCH had higher antioxidant properties by DPPH and ABTS radical scavenging assay and FRAP. The moisturizing properties on pig skin using a Corneometer(R)showed that 0.5% H-CMCH significantly presented (p <= 0.05) greater moisturizing effect than that of untreated-skin, distilled water, propylene glycol and pure chitosan from three molecular weights.
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