期刊
OPEN BIOLOGY
卷 10, 期 6, 页码 -出版社
ROYAL SOC
DOI: 10.1098/rsob.200097
关键词
chromosome organization; chromosome segregation; chromosome maintenance; ParA-ParB-parS; spreading; SMC
资金
- Royal Society [UF140053, RG150448]
- BBSRC [BBS/E/J/000C0683] Funding Source: UKRI
Proper chromosome segregation during cell division is essential in all domains of life. In the majority of bacterial species, faithful chromosome segregation is mediated by the tripartite ParABS system, consisting of an ATPase protein ParA, a CTPase and DNA-binding protein ParB, and a centromere-like parS site. The parS site is most often located near the origin of replication and is segregated first after chromosome replication. ParB nucleates on parS before binding to adjacent non-specific DNA to form a multimeric nucleoprotein complex. ParA interacts with ParB to drive the higher-order ParB-DNA complex, and hence the replicating chromosomes, to each daughter cell. Here, we review the various models for the formation of the ParABS complex and describe its role in segregating the origin-proximal region of the chromosome. Additionally, we discuss outstanding questions and challenges in understanding bacterial chromosome segregation.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据