期刊
COLLOID AND POLYMER SCIENCE
卷 294, 期 8, 页码 1251-1257出版社
SPRINGER
DOI: 10.1007/s00396-016-3880-0
关键词
P(NIPAM-co-AA); Nanogels; Fe3O4; In situ; MRI
资金
- National Nature Science Foundation of China [51473032, 51503034]
- Science and Technology Commission of Shanghai Municipality for Yangfan Program [15YF1400700]
- Fundamental Research Funds for the Central Universities [2232015D3-12]
- Shanghai Municipality research projects [13520720100]
The monodisperse and magnetic Fe3O4/poly(N-isopropylacrylamide-co-acrylic acid) nanogels (Fe3O4/P(NIPAM-co-AA)) have been synthesized successfully by in situ oxidation. Firstly, N-isopropylacrylamide (NIPAM) and acrylic acid (AA) were used as monomers to synthesize P(NIPAM-co-AA) nanogels by emulsion precipitation polymerization in aqueous solution, followed by in situ oxidation of Fe2+ into Fe3O4 nanocrystals inside the network of the P(NIPAM-co-AA) nanogels. The resulting magnetic nanogels had a very good superparamagnetic property measured with vibrating sample magnetometer (VSM) with magnetization value of 2.7 emu g(-1) and sensitive T (2)-weighted in vitro magnetic resonance imaging (MRI) with r (2) relaxivity of approximately 439.23 mM(-1) s(-1). This work would provide the possibility of using the novel Fe3O4/P(NIPAM-co-AA) nanogels as MRI contrast agent.
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