期刊
G3-GENES GENOMES GENETICS
卷 10, 期 9, 页码 3087-3097出版社
OXFORD UNIV PRESS INC
DOI: 10.1534/g3.120.401149
关键词
yeast; polyploidy; long-read sequencing; beer brewing; archeology
资金
- Natural Sciences and Engineering Research Council of Canada (NSERC)
- Genome Canada Grant (LSARP BIOSAFE)
- NSERC Alexander Graham Bell graduate fellowship
- Fonds de recherche sante Quebec (FRSQ) postdoctoral fellowship
The genome sequences of archeologicalSaccharomyces cerevisiaeisolates can reveal insights about the history of human baking, brewing and winemaking activities. A yeast strain called Jean-Talon was recently isolated from the vaults of the Intendant's Palace of Nouvelle France on a historical site in Quebec City. This site was occupied by breweries from the end of the 17(th)century until the middle of the 20(th)century when poisoning caused by cobalt added to the beer led to a shutdown of brewing activities. We sequenced the genome of the Jean-Talon strain and reanalyzed the genomes of hundreds of strains to determine how it relates to other domesticated and wild strains. The Jean-Talon strain is most closely related to industrial beer strains from the beer and bakery genetic groups from the United Kingdom and Belgium. It has numerous aneuploidies and Copy Number Variants (CNVs), including the main gene conferring cobalt resistance in yeast. The Jean-Talon strain has indeed higher tolerance to cobalt compared to other yeast strains, consistent with adaptation to the most recent brewing activities on the site. We conclude from this that the Jean-Talon strain most likely derives from recent brewing activities and not from the original breweries of Nouvelle France on the site.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据