4.3 Article

The Genome Sequence of the Jean-Talon Strain, an Archeological Beer Yeast from Quebec, Reveals Traces of Adaptation to Specific Brewing Conditions

期刊

G3-GENES GENOMES GENETICS
卷 10, 期 9, 页码 3087-3097

出版社

OXFORD UNIV PRESS INC
DOI: 10.1534/g3.120.401149

关键词

yeast; polyploidy; long-read sequencing; beer brewing; archeology

资金

  1. Natural Sciences and Engineering Research Council of Canada (NSERC)
  2. Genome Canada Grant (LSARP BIOSAFE)
  3. NSERC Alexander Graham Bell graduate fellowship
  4. Fonds de recherche sante Quebec (FRSQ) postdoctoral fellowship

向作者/读者索取更多资源

The genome sequences of archeologicalSaccharomyces cerevisiaeisolates can reveal insights about the history of human baking, brewing and winemaking activities. A yeast strain called Jean-Talon was recently isolated from the vaults of the Intendant's Palace of Nouvelle France on a historical site in Quebec City. This site was occupied by breweries from the end of the 17(th)century until the middle of the 20(th)century when poisoning caused by cobalt added to the beer led to a shutdown of brewing activities. We sequenced the genome of the Jean-Talon strain and reanalyzed the genomes of hundreds of strains to determine how it relates to other domesticated and wild strains. The Jean-Talon strain is most closely related to industrial beer strains from the beer and bakery genetic groups from the United Kingdom and Belgium. It has numerous aneuploidies and Copy Number Variants (CNVs), including the main gene conferring cobalt resistance in yeast. The Jean-Talon strain has indeed higher tolerance to cobalt compared to other yeast strains, consistent with adaptation to the most recent brewing activities on the site. We conclude from this that the Jean-Talon strain most likely derives from recent brewing activities and not from the original breweries of Nouvelle France on the site.

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