期刊
COLD SPRING HARBOR PERSPECTIVES IN MEDICINE
卷 11, 期 8, 页码 -出版社
COLD SPRING HARBOR LAB PRESS, PUBLICATIONS DEPT
DOI: 10.1101/cshperspect.a040287
关键词
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资金
- ZonMw (the Netherlands Organisation for Health Research and Development) [91214093]
- CNRS (Centre National de la Recherche Scientifique)
- Universite de Bordeaux
- FRM (Fondation pour la Recherche Medicale) [DPA20140629788]
Research on addictive behavior in laboratory animals, such as escalating drug use, strong motivation for drugs, and preference for drugs, allows us to understand the neural, genetic, and psychological background of addiction, which may ultimately contribute to the prevention and treatment of substance use disorders.
To more effectively manage substance use disorders, it is imperative to understand the neural, genetic, and psychological underpinnings of addictive behavior. To contribute to this understanding, considerable efforts have been made to develop translational animal models that capture key behavioral characteristics of addiction on the basis of DSM5 criteria of substance use disorders. In this review, we summarize empirical evidence for the occurrence of addiction-like behavior in animals. These symptoms include escalation of drug use, neurocognitive deficits, resistance to extinction, exaggerated motivation for drugs, increased reinstatement of drug seeking after extinction, preference for drugs over nondrug rewards, and resistance to punishment. The occurrence of addiction-like behavior in laboratory animals has opened the opportunity to investigate the neural, genetic, and psychological background of key aspects addiction, which may ultimately contribute to the prevention and treatment of substance use disorders.
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