期刊
CONTACT LENS & ANTERIOR EYE
卷 44, 期 1, 页码 72-75出版社
ELSEVIER
DOI: 10.1016/j.clae.2020.06.007
关键词
Silicone hydrogel; Hydrogel; Soft contact lenses; Cornea endothelial cells morphology
资金
- Universiti Kebangsaan Malaysia [NN2017-121]
This study analysed the alterations in corneal endothelial morphology induced by wearing soft contact lenses among young adults in Kuala Lumpur, and found that contact lens material and duration of wear are factors affecting these alterations. Optometrists are recommended to regularly evaluate the corneal endothelial cells of contact lens wearers and intervene when necessary.
Purpose: To analyse and compare the alterations in corneal endothelium morphology induced by different materials and durations of wearing soft contact lenses (CL) among young adults living in Kuala Lumpur. Methods: Healthy soft CL wearers were invited to participate in this study. Visual acuity (VA) was measured using the Snellen chart, and subjective refraction was performed using cross-cylinder technique. Standard ocular assessments were conducted using a slit lamp biomicroscope and morphology of corneal endothelial cells (endothelial cell density, ECD, coefficient variation, COV, hexagonality, HEX and central corneal thickness, CCT) were evaluated using a non-contact specular microscope. Statistical analysis was conducted using ANOVA and data from the right eye only is included. Results: A total of 72 subjects (32 SiHy and 40 HCL wearers) and 24 non-CL wearers (control) participated in this study. The gender distribution for study subjects was 13 males and 59 females, with a mean age 22.15 +/- 1.84 years old. The mean refraction was -1.86 +/- 1.25DS. The duration of wearing CL ranged from 1 to 9 years. Subjects were later divided into 2 groups following duration of CL wear: Group 1 ( < 5 years) and Group 2 (>= 5 years) for analysis purposes. Statistical analysis showed significant alterations in ECD, COV and HEX of CL wearers (p < 0.05), with more changes found in HCL and Group 2 wearers. No significant change was found in CCT. Conclusion: This study concludes that soft CL wear induced alterations in the morphology of corneal endothelial cells. Contact lens material and duration of CL wear (in years) are factors that affect the alterations. Optometrists are recommended to regularly evaluate the morphology of corneal endothelial cells in CL wearers and provide necessary intervention when required.
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