期刊
COGNITIVE NEUROPSYCHIATRY
卷 25, 期 4, 页码 281-293出版社
ROUTLEDGE JOURNALS, TAYLOR & FRANCIS LTD
DOI: 10.1080/13546805.2020.1779679
关键词
Fully-dimensional approach; Prepulse Inhibition; sensorimotor gating; schizotypal traits; quasi-dimensional approach
类别
资金
- ARISTEIA II Action of the Operational Programme Education and Lifelong Learning
- European Social Fund (ESF)
- [KA2990]
Introduction:According to thefully-dimensional approach, schizotypy is a personality trait present in the population in a continuous manner while thequasi-dimensional approachemphasises its extreme presentations. In this study we examined the relationship between sensorimotor gating, a core risk-index of the schizophrenia-spectrum, and four schizotypal factors in a dimensional-wise and a dichotomising-wise approach. Methods:Two-hundred and eighty-three participants were assessed with the Schizotypal Personality Questionnaire and were tested for Prepulse Inhibition (PPI). Associations between the schizotypal factors and startle measures were examined with stepwise regressions (dimensional-wise approach). Individuals in the lower 20% or the upper 20% for each schizotypal factor were identified and between-group comparisons were conducted (dichotomising-wise approach). Results:We found that with both approaches, only high paranoid or negative schizotypy were associated with reduced PPI. The low negative schizotypy group had prolonged onset and peak latencies, indicating that prolonged stimulus detection accompanies superior sensorimotor gating in this group. Conclusions:The findings suggest that although differentiating the effects of the various schizotypal factors is primary, the approach employed is secondary. The study also adds evidence in the literature supporting PPI as a useful endophenotypic marker of the schizophrenia-spectrum and highlights the contribution of specific aspects of schizotypy.
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