期刊
CELL REPORTS
卷 31, 期 12, 页码 -出版社
CELL PRESS
DOI: 10.1016/j.celrep.2020.107776
关键词
-
类别
资金
- NYU School of Medicine
- Cure Alzheimer's Foundation
- Glenn Foundation Glenn Award
- Gilbert Vision Restoration Initiative
- NIH [R01 EY062100, R01 EY027713]
- Stanford Vision Core [NIH P30 EY026877]
- Stanford University Interdisciplinary Graduate Fellowship
- Wu Tsai Neurosciences Institute
Glaucoma is a neurodegenerative disease that features the death of retinal ganglion cells (RGCs) in the retina, often as a result of prolonged increases in intraocular pressure. We show that preventing the formation of neuroinflammatory reactive astrocytes prevents the death of RGCs normally seen in a mouse model of glaucoma. Furthermore, we show that these spared RGCs are electrophysiologically functional and thus still have potential value for the function and regeneration of the retina. Finally, we demonstrate that the death of RGCs depends on a combination of both an injury to the neurons and the presence of reactive astrocytes, suggesting a model that may explain why reactive astrocytes are toxic only in some circumstances. Altogether, these findings highlight reactive astrocytes as drivers of RGC death in a chronic neurodegenerative disease of the eye.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据