期刊
ADVANCED HEALTHCARE MATERIALS
卷 9, 期 18, 页码 -出版社
WILEY
DOI: 10.1002/adhm.202000447
关键词
antibacterial nanopillars; initiated chemical vapor deposition; intraocular lenses; polymer nanopillar arrays; surface modification
资金
- National Research Foundation of Korea (NRF) - Ministry of Science, ICT & Future Planning [2017M3A7B4041761, 2018R1C1B3001553]
- Wearable Platform Materials Technology Center (WMC) - National Research Foundation of Korea (NRF) Grant of the Korean Government (MSIP) [2016R1A5A1009926]
- National Research Foundation of Korea (NRF) - Korea Government (MSIP) [2017R1A2B3007806]
- National Research Foundation of Korea [2018R1C1B3001553, 2017R1A2B3007806, 2017M3A7B4041754] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
Postsurgical intraocular lens (IOL) infection caused by pathogenic bacteria can result in blindness and often requires a secondary operation to replace the contaminated lens. The incorporation of an antibacterial property onto the IOL surface can prevent bacterial infection and postoperative endophthalmitis. This study describes a polymeric nanopillar array (NPA) integrated onto an IOL, which captures and eradicates the bacteria by rupturing the bacterial membrane. This is accomplished by changing the behavior of the elastic nanopillars using bending, restoration, and antibacterial surface modification. The combination of the polymer coating and NPA dimensions can decrease the adhesivity of corneal endothelial cells and posterior capsule opacification without causing cytotoxicity. An ionic antibacterial polymer layer is introduced onto an NPA using an initiated chemical vapor deposition process. This improves bacterial membrane rupture efficiency by increasing the interactions between the bacteria and nanopillars and damages the bacterial membrane using quaternary ammonium compounds. The newly developed ionic polymer-coated NPA exceeds 99% antibacterial efficiency againstStaphylococcus aureus, which is achieved through topological and physicochemical surface modification. Thus, this paper provides a novel, efficient strategy to prevent postoperative complications related to bacteria contamination of IOL after cataract surgery.
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