期刊
ADVANCED HEALTHCARE MATERIALS
卷 9, 期 13, 页码 -出版社
WILEY
DOI: 10.1002/adhm.201901812
关键词
bacteriolytic therapy; nano-bio emulsions; scintillating nanoparticles; tumor microenvironments; X-ray photodynamic therapy (PDT)
资金
- National Cancer Institute [R01CA218659, R01EB026207]
- National Institute of Biomedical Imaging and Bioengineering
- Korea Institute of Science and Technology Institutional Program [2E29290/CAP-16-02-KIST]
- Basic Science Research Program through the National Research Foundation of Korea - Ministry of Science and ICT (MSIT) [2018R1C1B6001120]
- National Research Foundation of Korea [2E30480] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
Various cancer therapies have been developed, but tumor recurrence with incomplete tumor killing and remaining tumor cells/tissues is frequent in monotherapies. Herein, a nano-bio therapeutic emulsion formulated with multifunctional nanoscintillators and anaerobicClostridium novyi-NT spores for synergistic image-guided combinational cancer therapy is reported. MRI visible nanoscintillators (NSs) are synthesized with a NaGdF4:Tb,Ce@NaGdF(4)core/shell structure for an image-guided X-ray photodynamic therapy (PDT) of the normoxic peripheral tumor. An anaerobic oncolytic bacterium (C. novyi-NT) therapy is combined to treat the hypoxic central tumor tissues. Photosensitizer-coated NSs (PS-NSs) andC. novyi-NT spores are emulsified with clinically available ethiodized oil (Lipiodol) to be the nano-bio therapeutic emulsion and injected into the tumor with computed tomography image guidance. The distribution of nano-bio therapeutic emulsion, including PS-NSs and anaerobicC. novyi-NT spores in the tumor site, is confirmed by both X-ray andT(1)-weighted magnetic resonance imaging. Following the image-guided X-ray PDT and anaerobicC. novyi- NT combination treatment, apoptotic cell death in cancer tissues, including both peripheral and central tumor regions, is significantly higher than in the control groups. This combination therapy approach using a nano-bio therapeutic emulsion is expected to overcome the limitations of conventional cancer therapy, resulting in increased cancer-therapeutic efficacy.
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