期刊
ADVANCED HEALTHCARE MATERIALS
卷 9, 期 16, 页码 -出版社
WILEY
DOI: 10.1002/adhm.202000607
关键词
cancer therapy; carbon dots; nucleolus targeting; photodynamic therapy; renal clearance
资金
- Natural Science Foundation of China [61805135, 61425006, 81772802, 61835009, 21808009]
- Pujiang Talents Program [18PJ1405100]
- Shanghai Jiao Tong University [ZH2018QNA43, YG2017MS19, YG2016MS22]
- Program of Shanghai Technology Research Leader [17XD1402200]
Photodynamic therapy (PDT), which utilizes light excited photosensitizers (PSs) to generate reactive oxygen species (ROS) and consequently ablate cancer cells or diseased tissue, has attracted a great deal of attention in the last decades due to its unique advantages. In order to further enhance PDT effect, PSs are functionalized to target specific sub-cellular organelles, but most PSs cannot target nucleolus, which is demonstrated as a more efficient and ideal site for cancer treatment. Here, an effective carbon dots (C-dots) photosensitizer with intrinsic nucleolus-targeting capability, for the first time, is synthesized, characterized, and employed for in vitro and in vivo image-guided photodynamic anticancer therapy with enhanced treatment performance at a low dose of PS and light irradiation. The C-dots possess high ROS generation efficiency and fluorescence quantum yield, excellent in vitro and in vivo biocompatibility, and rapid renal clearance, endowing it with a great potential for future translational research.
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