4.7 Article

Nanobottles for Controlled Release and Drug Delivery

期刊

ADVANCED HEALTHCARE MATERIALS
卷 10, 期 4, 页码 -

出版社

WILEY
DOI: 10.1002/adhm.202000587

关键词

controlled drug release; drug delivery; drug encapsulation; nanobottles; phase-change materials

资金

  1. Georgia Institute of Technology
  2. National Institutes of Health (NIH) [R01 CA138527]
  3. NIH Director's Pioneer Award [DP1 OD000798]

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Nanobottles are colloidal particles with a hollow interior and a single opening, making them ideal for loading, encapsulation, release, and delivery of therapeutic agents in biomedical applications. Control of release can be achieved by varying the opening size and integrating stimuli-responsive materials. Future directions for nanomaterials include manufacturing, functionalization, and application advancements.
Nanobottles refer to colloidal particles with a hollow interior and a single opening in the wall. These unique features make them ideal carriers for the loading, encapsulation, release, and delivery of various types of theranostic agents in an array of biomedical applications. The hollow interior gives them a high loading capacity while the opening enables quick loading and controlled release of the payload(s). More significantly, on-demand release can be readily achieved by adding a stimuli-responsive material as the inner matrix or cork stopper. This progress report begins with an introduction to the general structures and properties of nanobottles, followed by a brief discussion on the methods developed for their fabrication. The use of nanobottles for loading different types of payloads is then showcased, including small-molecule drugs, biomacromolecules, imaging contrast agents, and functional nanoparticles. The strategies explored for controlling the release by varying the size of the opening and/or integrating with a stimuli-responsive material are also highlighted. This paper concludes with some perspectives on future directions for this class of nanomaterials in terms of fabrication, functionalization, and application.

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