期刊
NUTRIENTS
卷 12, 期 7, 页码 -出版社
MDPI
DOI: 10.3390/nu12072089
关键词
MFGM; phospholipids; gangliosides; dairy; inflammation; polar lipids; anti-inflammatory; IL-1 beta; nitric oxide; superoxide anion; cyclo-oxygenase-2; neutrophil elastase
资金
- FOUNDATION FOR RESEARCH, SCIENCE, AND TECHNOLOGY, NEW ZEALAND [LPHM0201]
Numerous health related properties have been reported for bovine milk fat globule membrane (MFGM) and its components. Here we present novel data on the in vitro and in vivo anti-inflammatory activity of various MFGM preparations which confirm and extend the concept of MFGM as a dietary anti-inflammatory agent. Cell-based assays were used to test the ability of MFGM preparations to modulate levels of the inflammatory mediators IL-1 beta, nitric oxide, superoxide anion, cyclo-oxygenase-2, and neutrophil elastase. In rat models of arthritis, using MFGM fractions as dietary interventions, the phospholipid-enriched MFGM isolates were effective in reducing adjuvant-induced paw swelling while there was a tendency for the ganglioside-enriched isolate to reduce carrageenan-induced rat paw oedema. These results indicate that the anti-inflammatory activity of MFGM, rather than residing in a single component, is contributed to by an array of components acting in concert against various inflammatory targets. This confirms the potential of MFGM as a nutritional intervention for the mitigation of chronic and acute inflammatory conditions.
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