期刊
CNS & NEUROLOGICAL DISORDERS-DRUG TARGETS
卷 15, 期 9, 页码 1016-1029出版社
BENTHAM SCIENCE PUBL
DOI: 10.2174/1871527315666160915142244
关键词
Blood-brain barrier; tight junctions; scaffold proteins; zonula occludens; brain capillary endothelial cells; vascular permeability
A tight regulation of the neuroparenchymal microenvironment is imperative for proper neurological function. The flux of blood-borne ions and solutes is restricted by specialized tissue barriers and of the three main central nervous system barriers, the brain endothelium constituting the blood-brain barrier represents the major interface between blood and brain. At the basis of the blood-brain barrier are, next to an elaborate transporting machinery, tight junctions which create not only a paracellular diffusion constraint but also enable vectorial transport across the endothelial monolayer. Generally, tight junctions not only represent a cell-cell adhesion structure, but integrate various signaling pathways via large multiprotein complexes, thereby impacting upon processes such as cell proliferation, cytoskeletal rearrangement, and transcriptional control. This review provides an overview of tight junction morphology and discusses our current understanding of the molecular composition of endothelial tight junctions at the blood-brain barrier.
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