期刊
NUTRIENTS
卷 12, 期 8, 页码 -出版社
MDPI
DOI: 10.3390/nu12082237
关键词
ageing; older persons; sensible sun exposure; cutaneous synthesis; vitamin D-3; natural sunlight; serum 25(OH)D
资金
- Rocky Mountain Chapter of the American College of Sports Medicine
- University of Wyoming Department of Family and Consumer Sciences
Older adults are frequently cited as an at-risk population for vitamin D deficiency that may in part be due to decreased cutaneous synthesis, a potentially important source of cholecalciferol (vitamin D-3). Previous studies found that cutaneous D(3)production declines with age; however, most studies have been conducted ex vivo or in the photobiology lab. The purpose of this study was to characterize the response of vitamin D metabolites following a 30-min bout of sun exposure (15-min each to the dorsal and ventral sides) at close to solar noon in younger and older adults. Methods: 30 healthy individuals with skin type II/III were recruited; a younger cohort, aged 20-37 (n= 18) and an older cohort (n= 12), age 51-69 years. Exposure was at outer limits of sensible sun exposure designed to enhance vitamin D synthesis without increasing risk of photo ageing and non-melanoma skin cancer. Serum D(3)concentration was measured at baseline, 24, 48 and 72 h post-exposure. Serum 25(OH)D was measured at baseline and 72 h post-exposure plus 168 h post-exposure in the older cohort. Results: D(3)increased in response to sun exposure (time effect;p= 0.002) with a trend for a difference in D(3)between cohorts (time*group;p= 0.09). By regression modeling of continuous data, age accounted for 20% of the variation in D(3)production. D(3)production decreased by 13% per decade. Despite changes in D-3, however, serum 25(OH)D did not change from baseline to 72 or 168 h post exposure (p> 0.10). Conclusions: Serum D(3)concentration increased significantly in response to outdoor sun exposure in younger and older adults. While ageing may dampen cutaneous synthesis, sunlight exposure is still a significant source of vitamin D-3.
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