期刊
NUTRIENTS
卷 12, 期 6, 页码 -出版社
MDPI
DOI: 10.3390/nu12061896
关键词
antioxidant; left ventricular ejection fraction; oxidative stress; 6-min walk test
资金
- AstaReal Co., Ltd.
- JSPS KAKENHI [JP17K09527, 18K15904]
- Ministry of Health, Labor andWelfare [H29-027]
- MEXT*-Supported Program for the Strategic Research Foundation at Private Universities, 2014-2018 (*Ministry of Education, Culture, Sports, Science and Technology)
- [26507010]
- Grants-in-Aid for Scientific Research [18K15904] Funding Source: KAKEN
Astaxanthin has strong antioxidant properties. We conducted a prospective pilot study on heart failure (HF) patients with left ventricular (LV) systolic dysfunction to investigate improvements in cardiac function and exercise tolerance in relation to suppression of oxidative stress by 3-month astaxanthin supplementation. Oxidative stress markers-serum Diacron reactive oxygen metabolite (dROM), biological antioxidant potential (BAP), and urinary 8-hydroxy-2 '-deoxyguanosine (8-OHdG) concentrations, LV ejection fraction (LVEF), and 6-min walk distance (6MWD) were assessed before and after 3-month astaxanthin supplementation. Finally, the data of 16 HF patients were analyzed. Following 3-month astaxanthin supplementation, dROM level decreased from 385.6 +/- 82.6 U.CARR to 346.5 +/- 56.9 U.CARR (p= 0.041) despite no changes in BAP and urinary 8-OHdG levels. LVEF increased from 34.1 +/- 8.6% to 38.0 +/- 10.0% (p= 0.031) and 6MWD increased from 393.4 +/- 95.9 m to 432.8 +/- 93.3 m (p= 0.023). Significant relationships were observed between percent changes in dROM level and those in LVEF. In this study, following 3-month astaxanthin supplementation, suppressed oxidative stress and improved cardiac contractility and exercise tolerance were observed in HF patients with LV systolic dysfunction. Correlation between suppression of oxidative stress and improvement of cardiac contractility suggests that suppression of oxidative stress by astaxanthin supplementation had therapeutic potential to improve cardiac functioning.
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