期刊
JOURNAL OF DIABETES INVESTIGATION
卷 12, 期 4, 页码 625-632出版社
WILEY
DOI: 10.1111/jdi.13380
关键词
Body-weight fluctuation; Diabetes; Weight cycling
资金
- grant for Integrated Innovative Team for Major Human Diseases Program of Tongji Medical College, HUST
- National Key RAMP
- D Program of China [2016YFC0901203]
- National Natural Science Foundation of China [81974109, 81570740]
This meta-analysis revealed that weight cycling was a strong independent predictor of new-onset diabetes. Further studies are needed to detect the causal links between weight cycling and the risk of developing diabetes.
Aims/Introduction In this meta-analysis, we aimed to explore the association between bodyweight cycling (weight fluctuation) and the risk of developing diabetes. Materials and Methods We analyzed data from eligible cohort studies that assessed the association between weight cycling in adults and the risk of developing diabetes from online databases PubMed, Cochrane Library and EMBASE databases (1966 to April 2020). We pooled data using relative risks (RRs) with a random effects model. Results A total of 14 studies involving 253,766 participants, including 8,904 diabetes events, were included. One study included eight independent reports, resulting in 21 reports in 14 studies. Summary analysis showed that individuals who suffered weight cycling had a higher risk of diabetes (RR 1.23. 95% confidence interval 1.07-1.41;P = 0.003). However, the association between weight cycling and the risk of developing diabetes was not observed in obese participants (body mass index >= 30 kg/m(2);P = 0.08). Conclusions The present meta-analysis showed that weight cycling was a strong independent predictor of new-onset diabetes. Future studies are required to detect the causal links between weight cycling and the risk of developing diabetes.
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