期刊
JOURNAL OF COSMETIC DERMATOLOGY
卷 20, 期 2, 页码 460-465出版社
WILEY
DOI: 10.1111/jocd.13537
关键词
fractional CO(2)laser; melasma; micro-needling; tranexamic acid
类别
The study found that micro-needling and fractional CO(2) laser are equally safe and effective for delivering tranexamic acid in the treatment of facial melasma. Both techniques significantly reduced the severity of melasma, with no statistically significant differences between them.
Background Tranexamic acid (TXA) in oral, topical, and intra-dermal injection routes showed efficacy in melasma treatment. Micro-needling and fractional carbon dioxide (CO2) laser were reported to enhance the drug delivery of TXA. Aims This study aimed at comparing the use of micro-needling and fractional CO(2)laser for drug delivery of TXA in the treatment of facial melasma. Patients/Methods Thirty female patients with bilateral symmetrical facial melasma were subjected to micro-needling, for one side of the face, and fractional CO(2)laser, for the other, followed by an immediate topical application of TXA solution 4 mg/mL. Patients received six biweekly sessions. Results Two weeks after the last session, a significant reduction in baseline modified melasma area and severity index (mMASI) score was observed on both sides. The mean +/- SD baseline mMASI dropped from 3.43 +/- 1.84 to 1.59 +/- 1.51 (mean reduction 57.73%, P < .001) and from 3.51 +/- 1.84 to 1.78 +/- 1.51 (mean reduction 55.82%, P < .001) in the micro-needling-treated side and in the fractional CO(2)laser-treated side, respectively. However, no statistically significant differences were found between the two sides (P = .81). Conclusions Micro-needling and fractional CO(2)laser are equally safe and effective for the delivery of TXA in the treatment of facial melasma.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据