期刊
COMPUTATIONAL AND THEORETICAL CHEMISTRY
卷 1183, 期 -, 页码 -出版社
ELSEVIER
DOI: 10.1016/j.comptc.2020.112850
关键词
Sulforaphane; Antioxidant; ROS; Free radicals; DFT
资金
- Yazd University post-graduate school
Reactions of sulforaphane, the most important component of broccoli, with radicals have been studied using theoretical chemistry. Reliable methods of density functional theory have been used to study mechanisms of reaction of sulforaphane with reactive oxygen species: (OH)-O-center dot, (center dot)OCH3, (OOH)-O-center dot and O-2(center dot-). Three mechanisms of radical reactions have been considered: radical adduct formation (RAF), hydrogen atom transfer (HAT) and single electron transfer (SET). All studied reactions have been studied in gas phase, water and n-octanol solutions. Water is used as a model for blood serum and n-octanol mimics the role of lipid environment. In order to design more effective molecules, some derivatives of sulforaphane have been studied in terms of solubility and antioxidant activities. Radical stabilization energies are studied to determine radical scavenging ability of sulforaphane and its derivatives.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据