期刊
CLINICS AND RESEARCH IN HEPATOLOGY AND GASTROENTEROLOGY
卷 45, 期 3, 页码 -出版社
ELSEVIER MASSON, CORP OFF
DOI: 10.1016/j.clinre.2020.06.004
关键词
Myxoid hepatocellular adenoma; HNF1A mutated hepatocellular adenoma; Sonic hedgehog hepatocellular adenoma; PTGDS; ASS1+hepatocellular adenoma
Preoperative imaging and histopathology, immunohistochemistry and molecular analysis were conducted on a 53-year-old female patient with 2 hepatocellular adenomas. The findings indicated both lesions were myxoid HCA, ruling out other types.
Preoperative imaging and histopathology, immunohistochemistry and molecular analysis after resection of 2 hepatocellular adenomas (HCAs) (20 and 2cm) in a 53-year-old female patient were performed. On imaging, the large lesion resembled a myxoid HCA, while the small lesion resembled a more conventional HCA with a small myxoid/fluid area. On microscopy, the large lesion showed cords and nests of hepatocytes embedded in abundant myxoid matrix, while the small lesion resembled a conventional HCA with small foci of myxoid change and serosities; both consistent with a myxoid HCA. Immunophenotyping and molecular subtyping excluded inflammatory HCA, CTNNB1 mutated HCA and sonic hedgehog HCA, and was consistent with HNF1A mutated HCA. The myxoid change as well as the serosities may allow imaging diagnosis of myxoid HCA. As fluid vacuoles can also be present in ASS1+HCA, sonic hedgehog HCA has to be considered in the differential diagnosis. (C) 2020 Les Auteurs. Publie par Elsevier Masson SAS.
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