期刊
BMC ENDOCRINE DISORDERS
卷 20, 期 1, 页码 -出版社
BMC
DOI: 10.1186/s12902-020-00595-4
关键词
Acromegaly; Somatostatin receptor ligands; Treatment satisfaction; Patient reported outcomes; Questionnaire
资金
- Chiasma, Inc.
- Tulane University and Health Outcomes Solutions
BackgroundAcromegaly patients managed on Somatostatin receptor ligands (SRLs), the most common first-line pharmacotherapy for acromegaly, may still experience acromegaly symptoms such as headache, sweating, fatigue, soft tissue swelling, and joint pain, even those with normal IGF-1. Additionally, treatment with SRLs may cause injection site reactions and other side effects such as gastro-intestinal (GI) symptoms. This study utilized patient-reported outcome measures to examine the burden associated with acromegaly and its treatment for patients receiving a stable dose of long-acting SRLs in routine clinical practice.MethodsUS acromegaly patients on a stable dose of SRL seen by their treating healthcare provider in the past 12months completed a one-time online survey including the Acro-TSQ, an acromegaly-specific tool for assessing symptom burden and treatment satisfaction and convenience.ResultsOne hundred five patients were enrolled (mean age 49.9years, 79.1% female). Patients experienced numerous symptoms, including >80% who experienced joint pain, acro-fog, swelling of soft tissue, and fatigue/weakness. Many symptoms occurred constantly, while some occurred at the end of the injection cycle, even among those with IGF-1<= 1.0 ULN. Injection site reactions were common. Patients were moderately satisfied with their current treatment; symptoms and side effects often affected daily activities. On average, patients reported >3 acromegaly provider visits/year.ConclusionsDespite receiving a stable dose of SRL and regular visits with an acromegaly healthcare provider, US acromegaly patients in routine clinical practice, and even the subgroup with normal IGF-1, report significant burden of disease and treatment.
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