期刊
CLINICS IN LIVER DISEASE
卷 20, 期 2, 页码 339-350出版社
W B SAUNDERS CO-ELSEVIER INC
DOI: 10.1016/j.cld.2015.10.008
关键词
Nonalcoholic fatty liver disease; Weight loss; Diet; Exercise; Bariatric surgery
Nonalcoholic fatty liver disease (NAFLD) is the hepatic manifestation of the metabolic syndrome. NAFLD is the most common liver disease in developed countries. Weight reduction of 3% to 5% is associated with improved steatosis; reductions of 5% to 7% are necessary for decreased inflammation; with 7% to 10%, individuals may experience NAFLD/NASH remission and regression of fibrosis. No specific dietary intervention has proven beneficial beyond calorie restriction. Physical activity without weight loss seems to decrease hepatic steatosis. Bariatric surgery is associated with decreased cardiovascular risk and improved overall mortality in addition to reduction in hepatic steatosis, inflammation, and fibrosis.
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