期刊
CLINICS IN LIVER DISEASE
卷 20, 期 3, 页码 535-+出版社
W B SAUNDERS CO-ELSEVIER INC
DOI: 10.1016/j.cld.2016.02.010
关键词
Alcoholic liver disease; Malnutrition; Sarcopenia; Skeletal muscle loss; Myostatin; Molecular pathways; Mitochondria; Reactive oxygen species
资金
- NIH [RO1 DK 83414, R21 AA 022742, UO1 AA021893, UO1DK061732]
Malnutrition is the most frequent and nearly universal consequence in alcoholic liver disease (ALD) that adversely affects clinical outcomes. Sarcopenia, or skeletal muscle loss, is the major component of malnutrition in liver disease. There are no effective therapies to prevent or reverse sarcopenia in ALD because the mechanisms are not well understood. Consequences of liver disease including hyperammonemia, hormonal perturbations, endotoxemia and cytokine abnormalities as well as the direct effects of alcohol and its metabolites contribute to sarcopenia in ALD. This article focuses on the prevalence, methods to quantify malnutrition, specifically sarcopenia and potential therapies including novel molecular targeted treatments.
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