期刊
NATURE COMMUNICATIONS
卷 11, 期 1, 页码 -出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/s41467-020-17931-w
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资金
- CREST from JST [JPMJCR14D3]
- MEXT [17H03542, 17H05739, 17H05761, 19H04771, 19K06674, 18H05099, 19H04956, 20H05030, 18K06251]
- Takeda Science Foundation
- Cooperative Research of Network Joint Research Center for Materials and Devices
- Otsuka foundation
- Grants-in-Aid for Scientific Research [18K06251, 19K06674, 19H04956, 19H04771, 20H05030, 17H03542, 18H05099, 17H05761, 17H05739] Funding Source: KAKEN
The brain is organized morphologically and functionally into a columnar structure. According to the radial unit hypothesis, neurons from the same lineage form a radial unit that contributes to column formation. However, the molecular mechanisms that link neuronal lineage and column formation remain elusive. Here, we show that neurons from the same lineage project to different columns under control of Down syndrome cell adhesion molecule (Dscam) in the fly brain. Dscam1 is temporally expressed in newly born neuroblasts and is inherited by their daughter neurons. The transient transcription of Dscam1 in neuroblasts enables the expression of the same Dscam1 splice isoform within cells of the same lineage, causing lineage-dependent repulsion. In the absence of Dscam1 function, neurons from the same lineage project to the same column. When the splice diversity of Dscam1 is reduced, column formation is significantly compromised. Thus, Dscam1 controls column formation through lineage-dependent repulsion.
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