期刊
NATURE COMMUNICATIONS
卷 11, 期 1, 页码 -出版社
NATURE PORTFOLIO
DOI: 10.1038/s41467-020-17636-0
关键词
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资金
- Ministry of Health, Welfare, and Labour
- Japan Society for the Promotion of Science [23617024, 21590775, 15KT0009]
- Program for Initiative Research Project from Keio University
- Program for Initiative Research Project from Keio University Global Research Institute (KGRI)
- Program for an Integrated Database of Clinical and Genomic Information [JP16kk0205009]
- Platform Program for Promotion of Genome Medicine from Japan Agency for Medical Research and Development [JP17km0405103]
- Medical-Welfare-Food-Agriculture Collaborative Consortium Project from the Japan Ministry of Agriculture, Forestry, and Fisheries
- Grants-in-Aid for Scientific Research [23617024, 15KT0009] Funding Source: KAKEN
Supercentenarians (those aged >= 110 years) are approaching the current human longevity limit by preventing or surviving major illness. Identifying specific biomarkers conducive to exceptional survival might provide insights into counter-regulatory mechanisms against aging-related disease. Here, we report associations between cardiovascular disease-related biomarkers and survival to the highest ages using a unique dataset of 1,427 oldest individuals from three longitudinal cohort studies, including 36 supercentenarians, 572 semi-supercentenarians (105-109 years), 288 centenarians (100-104 years), and 531 very old people (85-99 years). During follow-up, 1,000 participants (70.1%) died. Overall, N-terminal pro-B-type natriuretic peptide (NT-proBNP), interleukin-6, cystatin C and cholinesterase are associated with all-cause mortality independent of traditional cardiovascular risk factors and plasma albumin. Of these, low NT-proBNP levels are statistically associated with a survival advantage to supercentenarian age. Only low albumin is associated with high mortality across age groups. These findings expand our knowledge on the biology of human longevity. Supercentenarians are approaching the current longevity limit by avoiding or surviving major illness, thus identifying biomarkers for exceptional survival might provide insights into the protection against disease of aging. Here, the authors show low NT-proBNP and high albumin in plasma are the biological correlates of survival to the highest ages.
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