期刊
NATURE COMMUNICATIONS
卷 11, 期 1, 页码 -出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/s41467-020-17183-8
关键词
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资金
- German Research Foundation (DFG) from the Interdisciplinary Center for Clinical Research (IZKF) within the faculty of Medicine at the RWTH Aachen University [SPP1656, HO2236/9-2, BL953/5-2, CRC1371, 395357507-SFB1371, CRC1382, 403224013 -SFB 1382, HO2236/14-1, HO2236/17-1]
- D2 seeding grant from School of Nutrition and Translational Research in Metabolism (NUTRIM) of Maastricht University
Following birth, the neonatal intestine is exposed to maternal and environmental bacteria that successively form a dense and highly dynamic intestinal microbiota. Whereas the effect of exogenous factors has been extensively investigated, endogenous, host-mediated mechanisms have remained largely unexplored. Concomitantly with microbial colonization, the liver undergoes functional transition from a hematopoietic organ to a central organ of metabolic regulation and immune surveillance. The aim of the present study was to analyze the influence of the developing hepatic function and liver metabolism on the early intestinal microbiota. Here, we report on the characterization of the colonization dynamics and liver metabolism in the murine gastrointestinal tract (n = 6-10 per age group) using metabolomic and microbial profiling in combination with multivariate analysis. We observed major agedependent microbial and metabolic changes and identified bile acids as potent drivers of the early intestinal microbiota maturation. Consistently, oral administration of tauro-cholic acid or beta-tauro-murocholic acid to newborn mice (n = 7 -14 per group) accelerated postnatal microbiota maturation.
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