期刊
NATURE COMMUNICATIONS
卷 11, 期 1, 页码 -出版社
NATURE PORTFOLIO
DOI: 10.1038/s41467-020-16785-6
关键词
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资金
- Ontario Institute for Cancer Research (OICR) through government of Ontario
- National Cancer Institute of the National Institutes of Health [5U24CA180951-04, 5U24CA210974-02]
- European Union's Framework Programme For Research and Innovation Horizon 2020 (2014-2020) under the Marie Curie Sklodowska-Curie Grant [703543]
- European Molecular Biology Laboratory (EMBL)
- Wellcome Trust [108437/Z/15/Z]
- National Science Foundation of USA [NSF IOS] [1127112]
- Open Targets
- Chan Zuckerberg Initiative
- joint BSC-IRB-CRG Program in Computational Biology [SEV 2015-0493]
- Severo Ochoa Award [SEV 2015-0493]
- Spanish Government [SEV 2015-0493]
- BSC-Lenovo Master Collaboration Agreement (2015)
- Wellcome Trust [108437/Z/15/Z] Funding Source: Wellcome Trust
The Pan-Cancer Analysis of Whole Genomes (PCAWG) project generated a vast amount of whole-genome cancer sequencing resource data. Here, as part of the ICGC/TCGA Pan-Cancer Analysis of Whole Genomes (PCAWG) Consortium, which aggregated whole genome sequencing data from 2658 cancers across 38 tumor types, we provide a user's guide to the five publicly available online data exploration and visualization tools introduced in the PCAWG marker paper. These tools are ICGC Data Portal, UCSC Xena, Chromothripsis Explorer, Expression Atlas, and PCAWG-Scout. We detail use cases and analyses for each tool, show how they incorporate outside resources from the larger genomics ecosystem, and demonstrate how the tools can be used together to understand the biology of cancers more deeply. Together, the tools enable researchers to query the complex genomic PCAWG data dynamically and integrate external information, enabling and enhancing interpretation.
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