期刊
NATURE COMMUNICATIONS
卷 11, 期 1, 页码 -出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/s41467-020-16630-w
关键词
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资金
- KIST intramural grants [2E30506, 2V07880, 2E30140]
- Samsung Research Funding & Incubation Center of Samsung Electronics [SRFC-TE19303-01]
- Brain Korea 21 Project - Ministry of Education of Korea
- National Research Foundation of Korea (NRF) Global Frontier Program [CAMM2019M3A6B3030638]
- National Research Council of Science & Technology (NST) - Korea government Ministry of Science and ICT [QLT-CRC-1802-KICT]
- National Research Foundation of Korea (NRF) - Korea government Ministry of Science and ICT [2017R1C1B2003585]
Toward the development of surface-sensitive analytical techniques for biosensors and diagnostic biochip assays, a local integration of low-concentration target materials into the sensing region of interest is essential to improve the sensitivity and reliability of the devices. As a result, the dynamic process of sorting and accurate positioning the nanoparticulate biomolecules within pre-defined micro/nanostructures is critical, however, it remains a huge hurdle for the realization of practical surface-sensitive biosensors and biochips. A scalable, massive, and non-destructive trapping methodology based on dielectrophoretic forces is highly demanded for assembling nanoparticles and biosensing tools. Herein, we propose a vertical nanogap architecture with an electrode-insulator-electrode stack structure, facilitating the generation of strong dielectrophoretic forces at low voltages, to precisely capture and spatiotemporally manipulate nanoparticles and molecular assemblies, including lipid vesicles and amyloid-beta protofibrils/oligomers. Our vertical nanogap platform, allowing low-voltage nanoparticle captures on optical metasurface designs, provides new opportunities for constructing advanced surface-sensitive optoelectronic sensors.
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