期刊
NATURE COMMUNICATIONS
卷 11, 期 1, 页码 -出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/s41467-020-17680-w
关键词
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资金
- Newton-Ungku Omar Fund [MR/P012930/1]
- Wellcome Trust [v203477/Z/16/Z]
- Malaysian Ministry of Science
- Malaysian Ministry of Higher Education High Impact Research Grant [UM.C/HIR/MOHE/06]
- Sime Darby LPGA tournament
- High Impact Research Grant
- Yayasan Sime Darby
- PETRONAS
- Estee Lauder Group of Companies
- NUS Start Up Grant
- National University Cancer Institute Singapore (NCIS) Centre Grant
- NMRC Clinical Scientist Award
- NMRC Clinician Scientist Award-Senior Investigator
- Asian Breast Cancer Research Fund
- Breast Cancer Prevention Programme under Saw Swee Hock School of Public Health
- Biomedical Research Council [05/1/21/19/425]
- L'Oreal-UNESCO For Women in Science National Fellowship
- National Research Foundation Singapore Fellowship [NRF-NRFF2017-02]
- Cancer Research-UK [C12292/A20861]
- Government of Canada through Genome Canada
- Canadian Institutes of Health Research
- Ministere de l'Economie et de l'Innovation du Quebec through Genome Quebec
- Quebec Breast Cancer Foundation
- CHU de Quebec Foundation
- Ontario Research Fund
- PERSPECTIVE project - Government of Canada through Genome Canada
- 'Ministere de l'Economie, de la Science et de l'Innovation du Quebec' through Genome Quebec
- NCI Genetic Associations and Mechanisms in Oncology (GAME-ON) initiative
- Discovery, Biology and Risk of Inherited Variants in Breast Cancer (DRIVE) project (NIH Grants) [U19 CA148065, X01HG007492]
- Cancer Research UK [C1287/A10118, C1287/A16563]
- Caucasian Community's Seventh Framework Programme [223175 (HEALTH-F2-2009-223175)]
- Caucasian Union's Horizon 2020 Research and Innovation Programme [633784, 634935]
- National Institute of Health (NIH) Cancer Post-Cancer GWAS initiative grant [U19 CA 148065]
- H2020 Societal Challenges Programme [633784, 634935] Funding Source: H2020 Societal Challenges Programme
- MRC [MR/P012930/1] Funding Source: UKRI
Polygenic risk scores (PRS) have been shown to predict breast cancer risk in European women, but their utility in Asian women is unclear. Here we evaluate the best performing PRSs for European-ancestry women using data from 17,262 breast cancer cases and 17,695 controls of Asian ancestry from 13 case-control studies, and 10,255 Chinese women from a prospective cohort (413 incident breast cancers). Compared to women in the middle quintile of the risk distribution, women in the highest 1% of PRS distribution have a similar to 2.7-fold risk and women in the lowest 1% of PRS distribution has similar to 0.4-fold risk of developing breast cancer. There is no evidence of heterogeneity in PRS performance in Chinese, Malay and Indian women. A PRS developed for European-ancestry women is also predictive of breast cancer risk in Asian women and can help in developing risk-stratified screening programmes in Asia.
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