期刊
ONCOLOGY LETTERS
卷 20, 期 4, 页码 -出版社
SPANDIDOS PUBL LTD
DOI: 10.3892/ol.2020.11897
关键词
ALL; adverse effects; CAR T; CD19; pediatric ALL
类别
资金
- Program of Cultivating Zhejiang Provincial High-Level Personnel in Health
- Chinese Medicine Research Program of Zhejiang Province [2020ZB148]
Chimeric antigen receptor (CAR) T cells have an unprecedented positive curative effect for hematological malignances. Most notably, cluster of differentiation 19 (CD19) CAR T-cell therapy for pediatric acute lymphoblastic leukemia is associated with a high complete remission rate and has aroused considerable attention in the medical field. However, it also causes a series of adverse reactions and increases the risk of recurrence. The present review examines the results of CD19 CAR T-cell therapy and lists its adverse effects. In addition, some of the mechanisms of recurrence are characterized and applicable strategies to address this challenging problem are proposed.
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