期刊
ONCOLOGY LETTERS
卷 20, 期 3, 页码 2587-2594出版社
SPANDIDOS PUBL LTD
DOI: 10.3892/ol.2020.11809
关键词
long non-coding RNA; GAS5; tumor suppressor gene; diagnostic biomarker; therapeutic targe
类别
资金
- Provincial Natural Science Foundation of Hunan [2019JJ50500, 2017JJ2226]
- Hunan Provincial Key Laboratory of Tumor Microenvironment Responsive Drug Research [Hunan Provincial Science and Technology Department Document] [2019-56]
- Scientific Research Fund of Hunan Provincial Education Department [17C1402]
- Hunan Province Cooperative Innovation Center for Molecular Target New Drug Study [2014-405]
- Undergraduate Research-based Learning and Innovative Experimental Program of University of South China [2017XJYZ040, 2018XJXZ348]
Long non-coding RNAs (lncRNAs) constitute a group of >200-nucleotide ncRNA molecules. lncRNAs regulate several cell functions, such as proliferation, apoptosis, invasion and metastasis. Meanwhile, lncRNAs are abnormally expressed in human malignancies, where they suppress or promote tumor growth. The present study focused on growth arrest-specific transcript 5 (GAS5), a well-known lncRNA that acts as a tumor suppressor but is suppressed in multiple types of cancer, including mammary carcinoma, prostate cancer, colorectal cancer, gastric cancer, melanoma, esophageal squamous cell carcinoma, lung cancer, ovarian cancer, cervical cancer, gliomas, osteosarcoma, pancreatic cancer, bladder cancer, kidney cancer, papillary thyroid carcinoma, neuroblastoma, endometrial cancer and liver cancer. Notably, GAS5 is overexpressed in liver cancer, potentially functioning as an oncogene. In the present study, the diagnostic and therapeutic roles of GAS5 in different tumors were reviewed, with a summary of the potential clinical application of the lncRNA, which may help identify novel study directions for GAS5.
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