期刊
EXPERIMENTAL AND THERAPEUTIC MEDICINE
卷 20, 期 4, 页码 2923-2940出版社
SPANDIDOS PUBL LTD
DOI: 10.3892/etm.2020.9073
关键词
acetylation; deacetylation; lysine acetyltransferase; lysine deacetylases; non-histone protein acetylation
资金
- Distinguished Professorship Program of National Research Program on prevention and control of major birth defects in reproductive health [2017YFC1000900]
- Special-funded Programme on National Key Scientific Instruments and Equipment Development [2016YFF0103800]
Cells primarily rely on proteins to perform the majority of their physiological functions, and the function of proteins is regulated by post-translational modifications (PTMs). The acetylation of proteins is a dynamic and highly specific PTM, which has an important influence on the functions of proteins, such as gene transcription and signal transduction. The acetylation of proteins is primarily dependent on lysine acetyltransferases and lysine deacetylases. In recent years, due to the widespread use of mass spectrometry and the emergence of new technologies, such as protein chips, studies on protein acetylation have been further developed. Compared with histone acetylation, acetylation of non-histone proteins has gradually become the focus of research due to its important regulatory mechanisms and wide range of applications. The discovery of specific protein acetylation sites using bioinformatic tools can greatly aid the understanding of the underlying mechanisms of protein acetylation involved in related physiological and pathological processes.
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