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Cindy R. Timme et al.
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Dipika Gupta et al.
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Ilaria Plantamura et al.
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H. Sun et al.
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Prabha Nagarajan et al.
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Ana Alcaraz-Sanabria et al.
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Christopher J. Lord et al.
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Prabha Nagarajan et al.
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Yi-Jung Ho et al.
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Destabilized SMC5/6 complex leads to chromosome breakage syndrome with severe lung disease
Saskia N. van der Crabben et al.
JOURNAL OF CLINICAL INVESTIGATION (2016)
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Y. S. Krasikova et al.
MOLECULAR BIOLOGY (2016)
Repair Pathway Choices and Consequences at the Double-Strand Break
Raphael Ceccaldi et al.
TRENDS IN CELL BIOLOGY (2016)
microRNA-206 impairs c-Myc-driven cancer in a synthetic lethal manner by directly inhibiting MAP3K13
Han Han et al.
ONCOTARGET (2016)
Cancer-Specific Synthetic Lethality between ATR and CHK1 Kinase Activities (vol 14, pg 298, 2016)
Kumar Sanjiv et al.
CELL REPORTS (2016)
miR-29s inhibit the malignant behavior of U87MG glioblastoma cell line by targeting DNMT3A and 3B
Hui Xu et al.
NEUROSCIENCE LETTERS (2015)
Glioblastoma: From Molecular Pathology to Targeted Treatment
Timothy F. Cloughesy et al.
ANNUAL REVIEW OF PATHOLOGY: MECHANISMS OF DISEASE, VOL 9 (2014)
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Lan N. Truong et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2014)
Identification of miRNA modulators to PARP inhibitor response
Sari Neijenhuis et al.
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Yi-Dong Chen et al.
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Lan N. Truong et al.
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SCIENCE TRANSLATIONAL MEDICINE (2013)
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Gavin P. Dunn et al.
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David Nittner et al.
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Jiri Sana et al.
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Over-expression of miR-100 is responsible for the low-expression of ATM in the human glioma cell line: M059J
Wooi Loon Ng et al.
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Aimee L. Jackson et al.
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Kinases that control the cell cycle in response to DNA damage: Chk1, Chk2, and MK2
H. Christian Reinhardt et al.
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Roger Stupp et al.
LANCET ONCOLOGY (2009)
MicroRNAs in diseases and drug response
Michela Garofalo et al.
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The DNA damage response: Ten years after
J. Wade Harper et al.
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Micrornas: Small RNAs with a big role in gene regulation
L He et al.
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Repair of DNA double strand breaks by non-homologous end joining
SP Lees-Miller et al.
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