期刊
ONCOTARGETS AND THERAPY
卷 13, 期 -, 页码 5429-5441出版社
DOVE MEDICAL PRESS LTD
DOI: 10.2147/OTT.S254995
关键词
erastin; ferroptosis; system X-C(-); p53; VDAC; cancer
资金
- Special Project of Medical and Health Professionals of Jilin Province, China [3D5197457429]
- Department of Science and Technology of Jilin Province, China [20160101119JC]
- Department of Finance of Jilin Province, China (Construction Project of Difficulty Gynecologic Oncology Hierarchical Diagnosis and Treatment Medical Association and Precision Radiotherapy Training Base)
Erastin was initially discovered as a small molecule compound that selectively kills tumor cells expressing ST and RAS(V12) and was later widely investigated as an inducer of ferroptosis. Ferroptosis is a recently discovered form of cell death caused by peroxidation induced by the accumulation of intracellular lipid reactive oxygen species (L-ROS) in an iron-dependent manner. Erastin can mediate ferroptosis through a variety of molecules including the cystine-glutamate transport receptor (system X-C(-)), the voltage-dependent anion channel (VDAC), and p53. Erastin is able to enhance the sensitivity of chemotherapy and radiotherapy, suggesting a promising future in cancer therapy. We hope that this review will help to better understand the role of erastin in ferroptosis and lay the foundation for further research and the development of erastin-based cancer therapies in the future.
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