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Cervical Cancer: Emerging Immune Landscape and Treatment

期刊

ONCOTARGETS AND THERAPY
卷 13, 期 -, 页码 8037-8047

出版社

DOVE MEDICAL PRESS LTD
DOI: 10.2147/OTT.S264312

关键词

immune; TIL; macrophage; immune therapy; checkpoint blockade

资金

  1. Research and Innovation Project of Shanghai Municipal Education Commission [2019-01-07-00-07-E00050]
  2. Shanghai Science and Technology Natural Science Foundation [19ZR1406900]

向作者/读者索取更多资源

Immune cells are essential for defending the body's balance and have increasingly been implicated in controlling tumor growth. In cervical cancer (CC), the immune landscape is extensively connected with human papillomavirus (HPV) status. Recent insights from studies have revealed that as a result of infection with HPV, immune cell populations such as lymphocytes or monocytes change during carcinogenesis. Immune therapy, in particular checkpoint inhibitors, those targeting PD-1 or PD-L1, has shown promising efficacy. This article reviews the immune landscape and immunotherapy of CC.

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