期刊
JOURNAL OF GERIATRIC ONCOLOGY
卷 12, 期 1, 页码 118-121出版社
ELSEVIER
DOI: 10.1016/j.jgo.2020.06.017
关键词
Pancreatic cancer; Geriatrics; Chemotherapy; Gemcitabine; Nab-paclitaxel; Adverse events
This study evaluated the efficacy and safety of modified gemcitabine plus nab-paclitaxel for older patients with pancreatic cancer. Results showed good efficacy with acceptable toxicity, with a median overall survival of 15.4 months and progression-free survival of 5.9 months in 34 patients.
Objectives: For older patients with pancreatic cancer (PC), the benefits of gemcitabine plus nab-paclitaxel (GnP) are still uncertain, and the toxicity may be excessive. We aimed to examine the efficacy and safety of modified GnP (m-GnP), which is a nab-paclitaxel reduced regimen, for older patients (>= 75 years) with advanced PC. Materials and Methods: In total, 34 patients met the eligibility criteria for study inclusion between 2015 and 2020. We evaluated the overall survival (OS), progression-free survival (PFS), best response, and adverse events associated with m-GnP treatment. Results: The median OS and PFS were 15.4 months and 5.9 months, respectively. The best response was partial response in 29% (10/34), stable disease in 53% (18/34), and progressive disease in 15% of patients (5/34); one patient was not evaluated. Among the grade 3 or higher hematological adverse events, neutropenia was the most frequent, occurring in 38% of patients (13/34), whereas febrile neutropenia occurred in 3% (1/34). Grade 3 or higher non-hematological adverse events occurred in 12% of patients (4/34). Early discontinuation owing to intolerable adverse events occurred in one patient, and there were no chemotherapy-related deaths. Conclusions: The present study demonstrated that m-GnP exhibited good efficacy with acceptable toxicity. To avoid early discontinuation and maintain dose intensities, initial dose reduction may be a good option for older patients with PC when receiving GnP. (C) 2020 Elsevier Ltd. All rights reserved.
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