期刊
VIRAL IMMUNOLOGY
卷 33, 期 9, 页码 594-599出版社
MARY ANN LIEBERT, INC
DOI: 10.1089/vim.2020.0039
关键词
picornavirus; type 1 diabetes; bio breeding rat; antiviral treatment
资金
- Karolinska University Hospital
- Karolinska Institutet [91201100915]
- Family Erling Persson Foundation
- Strategic Research Program in Diabetes at Karolinska Institutet
- Stichting af Jochnick Foundation
A Picornavirus (Ljungan virus [LV]) originally found in bank voles has been associated with type 1 diabetes (T1D) in its wild rodent reservoir, but also associated with T1D in a laboratory rat model for the disease, the diabetes prone (DP) Bio Breeding (BB) rat. Successful treatment of diabetes in this rat model, using experimental antiviral compounds directed against picornavirus, has been reported. In the present study we show significant clinical response in DP-BB rats using antiviral compounds available for human use (Pleconaril, Efavirenz, and Ribavirin). Presence of LV picornavirus antigen has been detected in islets of Langerhans from both human and the T1D rat model with clear morphological similarity. Based on these data it would be of interest to test antiviral treatment in patients with newly diagnosed T1D. Successful outcome will offer both proof of concept regarding the role of virus involvement in the disease and possibly a first generation treatment interrupting a persistent infection and stopping beta-cell destruction.
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