期刊
VETERINARY PATHOLOGY
卷 57, 期 5, 页码 700-705出版社
SAGE PUBLICATIONS INC
DOI: 10.1177/0300985820939976
关键词
AA amyloidosis; A beta amyloidosis; birds; central nervous system; flamingo; peripheral nervous system
资金
- JSPS KAKENHI [16H05027, 17K17702]
- TUAT president's discretionary funding
- Grants-in-Aid for Scientific Research [17K17702] Funding Source: KAKEN
AA amyloidosis is characterized by amyloid deposition in systemic organs, but amyloid deposition in the central nervous system (CNS) or peripheral nervous system (PNS) is rare. In this study, AA amyloidosis was observed in 31 of 48 flamingos that died at a Japanese zoo. Almost all cases developed AA amyloidosis secondary to inflammatory diseases such as enteritis. Affected flamingos had AA amyloid deposition around blood vessels in periventricular white matter of the brain and in peripheral nerves. In addition, cerebral A beta amyloidosis was observed in one of the 31 cases with AA amyloidosis. In conclusion, flamingos in the zoo commonly developed systemic amyloidosis with frequent amyloid deposition in the CNS and PNS, which seems to be a unique distribution in this avian species. Comparative pathological analyses in flamingos may help elucidate the pathogenesis of amyloid neuropathy.
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