期刊
CLINICAL SCIENCE
卷 130, 期 5, 页码 301-315出版社
PORTLAND PRESS LTD
DOI: 10.1042/CS20150547
关键词
abdominal aortic aneurysm; animal models; clinical trial; oxidative stress; pharmacotherapy
资金
- National Health and Medical Research Council [1063476, 1022752, 1021416, 1020955, 1003707]
- Practitioner Fellowship [1019921]
- Centre of Research Excellence [1000967]
- Queensland Government
- Townsville Hospital Private Practice Trust Fund
Abdominal aortic aneurysm (AAA) is a significant cause of mortality in older adults. A key mechanism implicated in AAA pathogenesis is inflammation and the associated production of reactive oxygen species (ROS) and oxidative stress. These have been suggested to promote degradation of the extracellular matrix (ECM) and vascular smooth muscle apoptosis. Experimental and human association studies suggest that ROS can be favourably modified to limit AAA formation and progression. In the present review, we discuss mechanisms potentially linking ROS to AAA pathogenesis and highlight potential treatment strategies targeting ROS. Currently, none of these strategies has been shown to be effective in clinical practice.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据