期刊
ULTRASOUND IN MEDICINE AND BIOLOGY
卷 46, 期 10, 页码 2785-2800出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.ultrasmedbio.2020.06.010
关键词
Strain imaging; Acute myocardial infarction; Animal model; Transthoracic echocardiography
资金
- National Institutes of Health [R01 EB006042, R01 HL140646]
Myocardial elastography (ME) is an ultrasound-based strain imaging method that aims to determine the degree of ischemia or infarction as a result of the change in the elastic properties of the myocardium. A survival canine model (n = 11) was employed to investigate the ability of ME to image myocardial infarction formation and recovery. Infarcts were generated by ligation of the left anterior descending coronary artery. Canines were survived and imaged for 4 days (n = 7) or 4 weeks (n = 4), allowing sufficient time for recovery via collateral perfusion. A radial strain-based metric, percentage of healthy myocardium by strain (PHM epsilon), was developed as a marker for healthy myocardial tissue. PHM epsilon was strongly linearly correlated with actual infarct size as determined by gross pathology (R-2 = 0.80). Mean PHM epsilon was reduced 1-3 days post-infarction (p < 0.05) at the papillary and apical short-axis levels; full infarct recovery was achieved by day 28, with mean PHM epsilon returning to baseline levels. ME was capable of diagnosing individual myocardial segments as non-infarcted or infarcted with high sensitivity (82%), specificity (92%) and precision (85%) (area under the receiver operating characteristic curve = 0.90). The study therefore strengthens the ME premise that it can detect and assess myocardial infarction progression and recovery in vivo and could thus provide an important role in both disease diagnosis and treatment assesssment. (E-mail: ek2191@columbia.edu) (C) 2020 World Federation for Ultrasound in Medicine & Biology. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据