4.7 Letter

Can CYP Inhibition Overcome Chemotherapy Resistance?

期刊

TRENDS IN PHARMACOLOGICAL SCIENCES
卷 41, 期 8, 页码 503-506

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CELL PRESS
DOI: 10.1016/j.tips.2020.05.007

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资金

  1. Swedish Research Council [2015-02760, 2016-01153, 2016-01154]
  2. EU's Horizon 2020 Research and Innovation Program U-PGx [668353]
  3. Swedish Research Council [2015-02760] Funding Source: Swedish Research Council
  4. H2020 Societal Challenges Programme [668353] Funding Source: H2020 Societal Challenges Programme

向作者/读者索取更多资源

A 2016 study proposed induction of the cytochrome P450 (CYP) enzyme CYP3A5 as a key mechanism for chemotherapy resistance and suggested CYP3A5 as a promising therapeutic target. However, in the context of the available literature we are skeptical that CYP3A5 contributes significantly to cancer drug resistance.

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