期刊
TRENDS IN GENETICS
卷 36, 期 6, 页码 403-414出版社
CELL PRESS
DOI: 10.1016/j.tig.2020.03.002
关键词
-
资金
- National Science Foundation [NSF-IOS-1754152]
In bilaterian animals, the mitochondrial genome is small, haploid, does not typically recombine, and is subject to accumulation of deleterious alleles via Muller's ratchet. These basic features of the genomic architecture present a paradox: mutational erosion of these genomes should lead to decline in mitochondrial function over time, yet no such decline is observed. Compensatory coevolution, whereby the nuclear genome evolves to compensate for the deleterious alleles in the mitochondrial genome, presents a potential solution to the paradox of Muller's ratchet without loss of function. Here, I review different proposed forms of mitonuclear compensatory coevolution. Empirical evidence from diverse eukaryotic taxa supports the mitonuclear compensatory coevolution hypothesis, but the ubiquity and importance of such compensatory coevolution remains a topic of debate.
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