期刊
TRENDS IN BIOCHEMICAL SCIENCES
卷 45, 期 6, 页码 472-483出版社
CELL PRESS
DOI: 10.1016/j.tibs.2020.02.010
关键词
-
资金
- National Institutes of Health [GM120604, GM069832, GM103368]
- RCSB Protein Data Bank (National Science Foundation) [DBI-1832184]
- RCSB Protein Data Bank (National Institutes of Health) [GM133198]
- RCSB Protein Data Bank (US Department of Energy) [DE-SC0019749]
Experimental information from microscopy, structural biology, and bioinformatics may be integrated to build structural models of entire cells with molecular detail. This integrative modeling is challenging in several ways: the intrinsic complexity of biology results in models with many closely packed and heterogeneous components; the wealth of available experimental data is scattered among multiple resources and must be gathered, reconciled, and curated; and computational infrastructure is only now gaining the capability of modeling and visualizing systems of this complexity. We present recent efforts to address these challenges, both with artistic approaches to depicting the cellular mesoscale, and development and application of methods to build quantitative models.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据