期刊
TRENDS IN BIOCHEMICAL SCIENCES
卷 45, 期 6, 页码 497-510出版社
CELL PRESS
DOI: 10.1016/j.tibs.2020.02.006
关键词
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资金
- United States National Institutes of Health [DK043093, DK055274]
- Fondation de France [DK043093, DK055274]
The actions of transcriptional coregulators are highly gene-specific, that is, each coregulator is required only for a subset of the genes regulated by a specific transcription factor. These coregulator-specific gene subsets often represent selected physiological responses amongmultiple pathways targeted by a transcription factor. Regulating the activity of a coregulator via post-translational modifications would thus affect only a subset of the transcription factor's physiological actions. Using the context of transcriptional regulation by steroid hormone receptors, this review focuses on gene-specific actions of coregulators and evidence linking individual coregulators with specific physiological pathways. Such evidence suggests that there is a `physiological coregulator code', which represents a fertile area for future research with important clinical implications.
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