Influence of immunosuppression on seroconversion against SARS-CoV-2 in two kidney transplant recipients

Solid organ transplant recipients are at risk for infectious complications due to chronic immunosuppression. The outbreak of coronavirus disease 2019 (COVID-19) in the United States has raised growing concerns for the transplant patient population. We seek to add to the current limited literature on COVID-19 in transplant recipients by describing the clinical course of two kidney transplant recipients with SARS-CoV-2 infection monitored by both RT-PCR and serology. Through careful adjustment of their immunosuppression regimen, both patients had excellent recovery with intact graft function and development of anti-SARS-CoV-2 antibodies.

Automated summary

This study adds to the limited literature on COVID-19 in transplant recipients by presenting the clinical course of two kidney transplant recipients with SARS-CoV-2 infection. Both patients had excellent recovery and developed anti-SARS-CoV-2 antibodies through careful adjustment of their immunosuppression regimen.