期刊
THYROID
卷 30, 期 11, 页码 1681-1684出版社
MARY ANN LIEBERT, INC
DOI: 10.1089/thy.2020.0315
关键词
familial dysalbuminemic hyperthyroxinemia; assay interference; discordant thyroid function tests; hypercortisolemia; albumin
资金
- Wellcome Trust [210755/Z/18/Z, 100237/Z/12/Z]
- NIHR Cambridge Biomedical Research Centre
- Royal Society
- MRC [MC_UU_00014/5, G0600717] Funding Source: UKRI
- Wellcome Trust [100237/Z/12/Z] Funding Source: Wellcome Trust
A 23-year-old man and his grandmother with hyperthyroxinemia and hypercortisolemia were heterozygous for anALBmutation (p. Arg218Pro), known to cause familial dysalbuminemic hyperthyroxinemia (FDH). However, serum-free cortisol levels in these individuals were normal and total cortisol concentrations fell markedly after depletion of albumin from their serum. We conclude that binding of steroid as well as iodothyronines to mutant albumin causes raised circulating cortisol as well as thyroid hormones in euthyroid euadrenal individuals with R218P FDH, with potential for misdiagnosis, unnecessary investigation, and inappropriate treatment.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据