期刊
TETRAHEDRON LETTERS
卷 61, 期 32, 页码 -出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tetlet.2020.152203
关键词
Saudiarabicains; 19-acetoxyingols; Euphorbia saudiarabica; P-glycoprotein; alpha-glucosidase inhibition
资金
- Institutional Development Award (IDeA) Network for Biomedical Research Excellence from the National Institute of General Medical Sciences of the National Institutes of Health [P20GM103430]
Five new 19-acetoxyingols were isolated from the aerial parts of Euphorbia saudiarabica. They included two uncommon pentacyclic acetoxyingols (1, 2) and two 2,3-diepimers (3, 4), representing the first report of 19-acetoxyingols epimers. Their structures were determined by analysis of extensive 1D and 2D NMR spectroscopic data. The absolute configurations were established by experimental and calculated CD analysis. Compounds 3-5 showed alpha-glucosidase inhibitory effects superior to the positive control, acarbose (IC50 9.1, 8.0, 1.8 vs 147 mu M, respectively). Compounds 1, 2, 4, and 5 showed inhibitory effects on human P-glycoprotein comparable to the positive control, valspodar (IC50 0.1-1.4 vs 0.2 mu M, respectively). (C) 2020 Elsevier Ltd. All rights reserved.
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